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Phenotypes Associated with This Genotype
Genotype
MGI:6279212
Allelic
Composition		 Ccm2tm1Mlkn/Ccm2tm1Mlkn
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1Mlkn mutation (0 available); any Ccm2 mutation (47 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal brain vasculature morphology ( J:250906 )
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13

nervous system
abnormal brain vasculature morphology ( J:250906 )
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
cerebral cavernous malformation 2 DOID:0060670 OMIM:603284
 J:250906

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory