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Phenotypes Associated with This Genotype
Genotype
MGI:6279212
Allelic
Composition
Ccm2tm1Mlkn/Ccm2tm1Mlkn
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccm2tm1Mlkn mutation (0 available); any Ccm2 mutation (39 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13

nervous system
• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cerebral cavernous malformation 2 DOID:0060670 OMIM:603284
J:250906


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory