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Phenotypes Associated with This Genotype
Genotype
MGI:6276576
Allelic
Composition
Tg(Mpz*S63X)31Mes/0
Genetic
Background
involves: FVB/N
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See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

muscle
• muscle atrophy in the hindlimbs

nervous system
• mice develop a neuromuscular disorder between 4-8 weeks of age
• sciatic nerve shows demyelinating neuropathy
• onion bulbs, signifying myelin destruction followed by attempts to remyelinate, are present at 6 months of age and increase in number with age
• 6 month old mice show demyelination and occasional onion bulbs in both ventral (motor) and dorsal (sensory) roots as well as in sciatic nerve
• hypomyelination with occasional nude axons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease type 1B DOID:0110152 OMIM:118200
J:105751


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory