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Phenotypes Associated with This Genotype
Genotype
MGI:6276568
Allelic
Composition
Tg(Mpz*S63C)32Mes/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

muscle
• muscle atrophy in the hindlimbs

nervous system
• mice develop a neuromuscular disorder between 4-8 weeks of age
• sciatic nerve shows demyelinating neuropathy
• onion bulbs, signifying myelin destruction followed by attempts to remyelinate, are present at 6 months of age and increase in number with age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease type 3 DOID:0050540 OMIM:145900
J:105751


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory