Phenotypes for Gt(ROSA)26Sor Pten Tg(Pbsn-cre)4Prb MGI:6275175 MGI Mouse

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:239660 )

• mice exhibit severely enlarged prostates with areas of solid tumor by 12 months of age

• 80% of mice display invasive, poorly differentiated carcinomas; tumors are highly proliferative with transitional sarcomatoid differentiation and maintain expression of androgen receptor

neoplasm

increased prostate gland adenocarcinoma incidence ( J:239660 )

• mice exhibit severely enlarged prostates with areas of solid tumor by 12 months of age

• 80% of mice display invasive, poorly differentiated carcinomas; tumors are highly proliferative with transitional sarcomatoid differentiation and maintain expression of androgen receptor

reproductive system

increased prostate gland adenocarcinoma incidence ( J:239660 )

• mice exhibit severely enlarged prostates with areas of solid tumor by 12 months of age

• 80% of mice display invasive, poorly differentiated carcinomas; tumors are highly proliferative with transitional sarcomatoid differentiation and maintain expression of androgen receptor

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:239660

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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