Phenotypes Associated with This Genotype

Genotype
MGI:6273176

• Allelic Composition: Mpz^tm1.1Wra/Mpz⁺
• Genetic Background: FVB.129S2-Mpz^tm1.1Wra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:267903 )

• P10-P12 mice show a reduction in motor coordination on the rotarod, however this defect is no longer present in adult P28 mice

• P10-P12 mice show a higher number of errors on the grid walking test, however this defect is no longer present in adult P28 mice

nervous system

abnormal axon radial sorting ( J:267903 )

• mice show an increase of bundles of unsorted mixed caliber axons in nerves at P11 that are not seen in wild-type nerves, however by P14, the radial sorting defect is no longer visible, indicating a delay in myelination

dysmyelination ( J:267903 )

• P28 sciatic nerves show a mild hypomyelination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuropathy		DOID:870		J:267903