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Phenotypes Associated with This Genotype
Genotype
MGI:6272036
Allelic
Composition
TnfBpsm1/TnfBpsm1
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
TnfBpsm1 mutation (0 available); any Tnf mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice become paralyzed around 6 weeks of age

cardiovascular system
• Background Sensitivity: aortic aneurism is much less pronounced on the C57BL/6 background than in mice on a BALB/c background
• aortic and mitral valve inflammation

craniofacial
• temporomandibular joints are severely affected

homeostasis/metabolism

immune system
• aortic and mitral valve inflammation
• temporomandibular joints are severely affected
• mice develop polyarthritis at an accelerated rate compared to heterozygotes
• polyarthritis is due to abnormal proliferation of synoviocytes and high mechanical stress

limbs/digits/tail
• 3 week old mice exhibit clubbed wrists

mortality/aging
N
• Background Sensitivity: no mice on the C57BL/6 background die up to 200 days of age while sudden death is seen on the BALB/c background

skeleton
• temporomandibular joints are severely affected
• mice develop polyarthritis at an accelerated rate compared to heterozygotes
• polyarthritis is due to abnormal proliferation of synoviocytes and high mechanical stress
• 3 week old mice exhibit clubbed wrists
• 3 week old mice exhibit luxated ankles

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:226052


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory