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Phenotypes Associated with This Genotype
Genotype
MGI:6272015
Allelic
Composition
Tnni2tm1Sgao/Tnni2+
Genetic
Background
involves: 129 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnni2tm1Sgao mutation (0 available); any Tnni2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• 2.4-fold compared with wild-type mice
• delayed cartilage ossifications in the ribs, carpus and metacarpus, phalanx, growth plates of the radii and ulna, and tail cartilage at P2, P5, P6, and P10
• impeded primary and secondary ossification centers in the long bones
• failure of vascular canal invasion at P6 in the radii
• absent mineralization of the matrix and hypertrophic chondrocytes at P6 in nasal cartilage
• surrounding the trabecular bone in the radii and ulnae
• in the radii and ulnae
• absent mineralization of the matrix and hypertrophic chondrocytes at P6 in nasal cartilage

growth/size/body
• from P5 to P20

homeostasis/metabolism
• reduced type I collagen in the radii and ulnae

cardiovascular system
• failure of vascular canal invasion at P6 in the radii

cellular
• 2.4-fold compared with wild-type mice

limbs/digits/tail
• contracture
• short at P12


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/07/2020
MGI 6.14
The Jackson Laboratory