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Phenotypes Associated with This Genotype
Genotype
MGI:6270171
Allelic
Composition
Tg(Camk2a-Polg*D181A)BTkato/0
Genetic
Background
C57BL/6J-Tg(Camk2a-Polg*D181A)BTkato
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice weigh about 10% less than controls, however there is no difference in food intake per body weight suggesting that lower weight is due to reduced food intake

behavior/neurological
N
• 22-29 week old males exhibit normal motor coordination and normal fatigue resistance in the rotarod and treadmill tests
• 18-27 week old males show normal ambulatory activity in the open field test, normal grooming, rearing, jumping, defecation and urination, and normal behavior in the elevated plus-maze test, no differences in the immobility time in the forced swimming test, in the novel-object recognition test, and in conditioned fear learning test
• 21-28 week old males eat less than wild-type mice
• mice exhibit increased freezing in the conditioning phase of the fear-learning test but no other differences in this test
• the amplitude of the acoustic startle response is increased in 18-27 week old males
• total wheel running activity is decreased
• mice exhibit altered intra-day activity rhythm, characterized by prolonged activity duration such as delayed and anticipatory activity; longer duration of activity is accompanied by lower intensity of activity
• however, mice do not show impairment in the circadian clock machinery
• chronic treatment with a tricyclic antidepressant, amitriptyline, induces manic switch-like behavior in some mice and worsens the distorted day-night rhythm; mice continue to show increased activity after termination of treatment indicating long-lasting influence of the drug
• females exhibit estrous cycle-associated fluctuation in wheel-running activity that is most prominent around 30-40 weeks after birth and disappears over 60 weeks of age
• lithium treatment improves the periodic activity change associated with the estrous cycle in females and the distorted day-night rhythm, but has no effect on the level of wheel-running activity

homeostasis/metabolism
• 22-32 week old males exhibit increased dopamine (DA) levels in the hippocampus and decreased DA levels in the amygdala
• dopamine levels, assessed by 3,4-dihydroxyphenylacetic acid (DOPAC)/DA or homovanillic acid (HVA/DA) ratios, are increased in the amygdala and decreased in the hippocampus of 22-32 week old males
• 22-32 week old males exhibit decreased noradrenaline levels
• 22-32 week old males exhibit a 67% and 86% decrease in serotonin (5-HT) levels in the amygdala and hippocampus, respectively
• serotonin turnover is increased in the amygdala and hippocampus of 22-32 week old males

nervous system
• 22-32 week old males exhibit decreased noradrenaline levels
• 22-32 week old males exhibit a 67% and 86% decrease in serotonin (5-HT) levels in the amygdala and hippocampus, respectively
• serotonin turnover is increased in the amygdala and hippocampus of 22-32 week old males

cellular
• mice exhibit mtDNA defects in the brain, with 68 week old mice showing deleted mtDNAs of about 2 kb
• small mtDNAs accumulate first in the hippocampus and cortex at 17 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
bipolar disorder DOID:3312 J:127895
mood disorder DOID:3324 J:127895


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory