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Phenotypes Associated with This Genotype
Genotype
MGI:6258952
Allelic
Composition
Cfap43em1Fzh/Cfap43em1Fzh
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfap43em1Fzh mutation (0 available); any Cfap43 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• no normal sperm flagella are seen
• sperm flagella are distorted and contain excess cytoplasm
• outer dense fibers of testicular spermatozoa are scattered and disordered
• testicular spermatozoa lack the central pair of microtubules and the 9 peripheral microtubule doublets are disordered
• 4.5-8% of sperm show irregular flagella caliber
• 8-13.5% of sperm show absent flagella
• 30.5-34.5% of sperm have coiled flagella
• 4-8.5% of sperm show sperm angulation
• 36-52.5% of sperm show short flagella
• sperm count is decreased
• severe defects in sperm motility
• cauda epididymides show shedding of residual bodies, abnormal cells, and disorganized spermatozoa with flagellar malformations
• however, spermatogonia and spermatocytes in seminiferous tubules have normal morphology
• males are infertile

cellular
• no normal sperm flagella are seen
• sperm flagella are distorted and contain excess cytoplasm
• outer dense fibers of testicular spermatozoa are scattered and disordered
• testicular spermatozoa lack the central pair of microtubules and the 9 peripheral microtubule doublets are disordered
• 4.5-8% of sperm show irregular flagella caliber
• 8-13.5% of sperm show absent flagella
• 30.5-34.5% of sperm have coiled flagella
• 4-8.5% of sperm show sperm angulation
• 36-52.5% of sperm show short flagella
• sperm count is decreased
• severe defects in sperm motility

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
spermatogenic failure 19 DOID:0070170 OMIM:617592
J:258613


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory