Phenotypes for Cfap44 MGI:6258951 MGI Mouse

reproductive system

abnormal sperm flagellum morphology ( J:258613 )

• no normal sperm flagella are seen

• sperm flagella are distorted and contain excess cytoplasm

• 6.3% of sperm show irregular flagellum caliber

abnormal outer dense fiber morphology ( J:258613 )

• outer dense fibers of the spermatozoa are scattered and disordered

abnormal sperm axoneme morphology ( J:258613 )

• sperm lack the central pair of microtubules and the 9 peripheral microtubule doublets are scattered and disordered

absent sperm axonemal central pair ( J:258613 )

absent sperm flagellum ( J:258613 )

• 12% of sperm show absent flagella

coiled sperm flagellum ( J:258613 )

• 25.8% of sperm show coiled flagella

kinked sperm flagellum ( J:258613 )

• 5.5% of sperm show angulation

short sperm flagellum ( J:258613 )

• 50.4% of sperm show short flagella

oligozoospermia ( J:258613 )

• sperm count is decreased

asthenozoospermia ( J:258613 )

• severe defects in sperm motility

abnormal cauda epididymis morphology ( J:258613 )

• cauda epididymides show shedding of residual bodies, abnormal cells, and disorganized spermatozoa with flagellar malformations

• however, spermatogonia and spermatocytes in seminiferous tubules have normal morphology

male infertility ( J:258613 )

• males are infertile

cellular