Phenotypes Associated with This Genotype

Genotype
MGI:6256808

• Allelic Composition: Tg(Scgb1a1-rtTA)1Jaw/0; Tg(tetO-EGFR*)#Kkw/0
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased lung tumor incidence ( J:156440 , J:235747 )

• doxycycline treated mice develop lung cancer (J:156440)

• mice treated with the WZ4002 compound show an increase in cell apoptosis and decrease in cell proliferation and regression of tumors (J:156440)

• treatment together with the compound EAI045 (an allosteric tyrosine kinase inhibitor) and cetuximab has no effect on tumor growth (J:235747)

respiratory system

increased lung tumor incidence ( J:156440 , J:235747 )

• doxycycline treated mice develop lung cancer (J:156440)

• mice treated with the WZ4002 compound show an increase in cell apoptosis and decrease in cell proliferation and regression of tumors (J:156440)

• treatment together with the compound EAI045 (an allosteric tyrosine kinase inhibitor) and cetuximab has no effect on tumor growth (J:235747)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:156440 , J:235747