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Phenotypes Associated with This Genotype
Genotype
MGI:6226150
Allelic
Composition
Lama2dy-Pas/Lama2dy-Pas
Genetic
Background
involves: non-inbred stock
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2dy-Pas mutation (0 available); any Lama2 mutation (106 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

mortality/aging
• mice do not live longer than 13 weeks

growth/size/body
• mice remain small
• mice become cachectic and poorly active after weaning and become extremely weak and cachectic in the last 3 weeks of life

behavior/neurological
• when held by the tail, mice are unable to keep their posterior legs in a tonic flexion position and present repetitive jerking movements of flexion and extension
• by 2 weeks of age, mice are less active than controls
• within 3 weeks, mice start waddling and eventually develop contractures, joint deformities and weakness
• posterior legs become immobilized and mice drag themselves
• anterior legs are affected such that mice support themselves on their elbows
• spontaneous breeding of homozygotes was not obtained

muscle
• peri- and endomysial connective tissue proliferation is seen between individual muscle fibers
• muscle shows variation in fiber size
• mice eventually develop weakness and lose mobility control

respiratory system
• mice present polypnea in the last 3 weeks of life

skeleton
• mice develop kyphoscoliosis
• mice eventually develop joint deformities
• mice eventually develop contractures

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital merosin-deficient muscular dystrophy 1A DOID:0110636 OMIM:607855
J:102806


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory