Phenotypes Associated with This Genotype

Genotype
MGI:6197223

• Allelic Composition: Tg(Cebpb-tTA)5Bjd/0; Tg(tetO-MYC,-OVAL)#Gtgm/0
• Genetic Background: B6J.Cg-Tg(Cebpb-tTA)5Bjd Tg(tetO-MYC,-OVAL)#Gtgm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:186226 )

• mice become moribund with multifocal hepatocellular carcinoma within 5-8 weeks when doxycycline is removed at birth

neoplasm

increased hepatocellular carcinoma incidence ( J:186226 )

• mice develop multifocal hepatocellular carcinoma within 5-8 weeks of birth, with initial tumor foci as early as 4 weeks after induction with the removal of doxycline

immune system

abnormal immune tolerance ( J:186226 )

• CD8+ T cells from Tg(TcraTcrb)1100Mjb expressing mice transferred into these mice are hyporesponsive and fail to become cytotoxic effect cells indicating cytotoxic T lymphocyte tolerance induction

liver/biliary system

increased hepatocellular carcinoma incidence ( J:186226 )

• mice develop multifocal hepatocellular carcinoma within 5-8 weeks of birth, with initial tumor foci as early as 4 weeks after induction with the removal of doxycline

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:186226