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Phenotypes Associated with This Genotype
Genotype
MGI:6195067
Allelic
Composition
Pmltm1.1Ews/Pmltm1.1Ews
Tg(PML-RARA)556Kog/0
Genetic
Background
FVB.Cg-Pmltm1.1Ews Tg(PML-RARA)556Kog
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmltm1.1Ews mutation (0 available); any Pml mutation (60 available)
Tg(PML-RARA)556Kog mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• primary MEFs show a defect in nonhomologous end-joining (NHEJ)

hematopoietic system
• leukemia is characterized by hyperleukocytosis

homeostasis/metabolism
• primary MEFs show a defect in nonhomologous end-joining (NHEJ)

immune system
• leukemia is characterized by hyperleukocytosis

neoplasm
• mice develop acute promyelocytic leukemia spontaneously with a frequency of 13.8% at 18 months of age
• leukemias are characterized by hyperleukocytosis, anemia, and thrombocytosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute promyelocytic leukemia DOID:0060318 OMIM:612376
J:262172


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory