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Phenotypes Associated with This Genotype
Genotype
MGI:6192107
Allelic
Composition
Tg(Ela1-Tgfa)150Bri/0
Trp53tm1Tyj/Trp53+
Genetic
Background
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ela1-Tgfa)150Bri mutation (0 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days
• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

neoplasm
• 77.3% of mice develop pancreatic tumors with a mean tumor-free survival of 220 days
• tumors sometimes show loss of heterozygosity for Trp53, Inkra/Arf, and/or Smad4

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:67389


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory