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Phenotypes Associated with This Genotype
Genotype
MGI:6187717
Allelic
Composition
Tardbpem1Rhbr/Tardbpem1Rhbr
Genetic
Background
C57BL/6J-Tardbpem1Rhbr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tardbpem1Rhbr mutation (1 available); any Tardbp mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• not alterations in circadian rhythmicity
• learning deficits observed by 4 months of age
• increase in number of training sessions for five choice serial reaction time task (measure of frontal function) to reach performance criteria as compared to wild-type
• deficit in choice phase of spontaneous object recognition task
• inattention phenotype reflecting frontal or executive dysfunction
• increased eating by hand by 4 months of age
• reduced hanging by 4 months of age
• in males, reduced rotarod latency is observed in a 6 month old cohort
• reduced walking by 4 months of age
• increased rearing by 4 months of age
• marble burying (innate digging) behavior is decreased in some mutants, however, other mutants perform similar to wild-type

growth/size/body
• weight gain due to hyperphagia

nervous system
N
• no evidence is found for impairment of motor coordination or denervation or motor unit loss of the lower motor neurons
• no alteration is observed in cortical thickness or cellular density
• 25% reduction of parvalbumin-positive interneurons in the frontal cortex
• 25% reduction of parvalbumin-positive interneurons in the frontal cortex

mortality/aging
• reduced numbers of males are produced


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory