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Phenotypes Associated with This Genotype
Genotype
MGI:6163836
Allelic
Composition
Pole4tm1(KOMP)Vlcg/Pole4tm1(KOMP)Vlcg
Trp53tm1Brd/Trp53+
Genetic
Background
involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pole4tm1(KOMP)Vlcg mutation (0 available); any Pole4 mutation (4 available)
Trp53tm1Brd mutation (7 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• unlike single Pole4tm1(KOMP)Vlcg homozygotes, which are essentially embryonic lethal in the inbred C57BL/6 background, mice are born at slightly sub-Mendelian ratios (10.1% born versus 12.5% expected)

behavior/neurological
• loss of rotarod coordination, observed in single Pole4tm1(KOMP)Vlcg homozygotes, is not rescued by deleting a single Trp53 allele

immune system

hematopoietic system

neoplasm
• ~90% of mice present with lymphomas
• lymphoma-free survival is significantly reduced to 226 days relative to 480 days in Trp53tm1Brd heterozygotes, indicating accelerated tumorigenesis

endocrine/exocrine glands
• ~90% of mice present with lymphomas


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory