Analysis Tools
reproductive system
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• most sperm show abnormal morphology like tail bending, decollation and head deformities
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• sperm show tail bending
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• most sperm show head deformities
• however, the acrosome is present and sperm chromatin integrity is normal
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• at 10 to 12-weeks of age, mature spermatids in cauda epididymides are markedly decreased, and cauda epididymides are full of round spermatids with abnormally shaped nuclei shedding from the seminiferous tubules
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• elongating spermatids show abnormal manchette morphology
• after step 10 of spermiogenesis, the microtubules of manchette are unable to move caudally down the nucleus and the perinuclear ring of the manchette fails to constrict; as a result, the portion of the nucleus next to the connecting piece is wider than in wild-type controls, causing a hammer-head sperm shape
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• perinuclear ring fails to constrict as the manchette moves toward the spermatid tail
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• at 10 to 12-weeks of age, the proportion of elongated spermatids is lower than that in wild-type testes, with only a few mature spermatids found in the cauda epididymides
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• at 10 to 12-weeks of age, the total count of cauda epididymides sperm is dramatically decreased
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• at 10 to 12-weeks of age, the percentages of motile and progressive sperm are dramatically decreased
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small testis
(
J:262160
)
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• at 10 to 12-weeks of age, post-meiotic development of elongating spermatids in stage VII seminiferous tubules is disrupted
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• male homozygotes are sterile due to severe oligoasthenoteratozoospermia
• mating behavior is normal
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cellular
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• most sperm show abnormal morphology like tail bending, decollation and head deformities
|
|
|
• sperm show tail bending
|
|
|
• most sperm show head deformities
• however, the acrosome is present and sperm chromatin integrity is normal
|
|
|
• at 10 to 12-weeks of age, mature spermatids in cauda epididymides are markedly decreased, and cauda epididymides are full of round spermatids with abnormally shaped nuclei shedding from the seminiferous tubules
|
|
|
• elongating spermatids show abnormal manchette morphology
• after step 10 of spermiogenesis, the microtubules of manchette are unable to move caudally down the nucleus and the perinuclear ring of the manchette fails to constrict; as a result, the portion of the nucleus next to the connecting piece is wider than in wild-type controls, causing a hammer-head sperm shape
|
|
|
• perinuclear ring fails to constrict as the manchette moves toward the spermatid tail
|
|
|
• at 10 to 12-weeks of age, the proportion of elongated spermatids is lower than that in wild-type testes, with only a few mature spermatids found in the cauda epididymides
|
|
|
• at 10 to 12-weeks of age, the total count of cauda epididymides sperm is dramatically decreased
|
|
|
• at 10 to 12-weeks of age, the percentages of motile and progressive sperm are dramatically decreased
|
endocrine/exocrine glands
small testis
(
J:262160
)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| oligoasthenoteratozoospermia | DOID:0070311 | J:262160 | ||
