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Phenotypes Associated with This Genotype
Genotype
MGI:6162247
Allelic
Composition
Spata16em2Osb/Spata16em2Osb
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/6NSlc * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spata16em2Osb mutation (3 available); any Spata16 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• testis size is significantly decreased relative to that in wild-type controls
• testis weight is significantly lower than that in wild-type controls
• rate of normal spermatogenesis is significantly reduced with 30/86 tubules observed in mutant testes versus 103/103 tubules in wild-type controls
• only a few spermatozoa are detected in the tubules of the caput and cauda epididymides, unlike in wild-type controls
• 7% of spermatozoa extracted from the cauda epididymis show abnormal head and tail morphology
• however, globozoospermia is not observed
• differentiation of round spermatids into mature spermatozoa is impaired
• almost all cells extracted from the cauda epididymis are arrested at the round spermatid stage
• adult male homozygotes are completely infertile due to a spermiogenic arrest
• mating behavior, ejaculation, and vaginal plug formation are normal
• female fertility is normal

cellular
• only a few spermatozoa are detected in the tubules of the caput and cauda epididymides, unlike in wild-type controls
• 7% of spermatozoa extracted from the cauda epididymis show abnormal head and tail morphology
• however, globozoospermia is not observed

endocrine/exocrine glands
• testis size is significantly decreased relative to that in wild-type controls
• testis weight is significantly lower than that in wild-type controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
male infertility DOID:12336 J:258202


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory