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Phenotypes Associated with This Genotype
Genotype
MGI:6160009
Allelic
Composition
Ecel1em1Hiki/Ecel1em1Hiki
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ecel1em1Hiki mutation (0 available); any Ecel1 mutation (23 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• mutants exhibit a variable penetrance of defects in axon guidance of abducens nerves, with the abducens nerves stopping extension of their axons towards the target muscles around the eye is some mutants at E11.5 and substantial numbers of abducens nerves following the wrong pathway in some mutants and some stopping extension of their axons toward their target muscles without any correct innervation at E12.5, indicating axon guidance defects
• abnormal motor innervation is seen in the hindlimbs (J:262090)
• the number of motor nerve terminals is decreased in the gracilis anterior muscle and the rectus femoris muscle (J:262090)
• axonal arborization of motor nerves is impaired in the diaphragm
• reduction in nerve length of abducens nerves

cellular
• mutants exhibit a variable penetrance of defects in axon guidance of abducens nerves, with the abducens nerves stopping extension of their axons towards the target muscles around the eye is some mutants at E11.5 and substantial numbers of abducens nerves following the wrong pathway in some mutants and some stopping extension of their axons toward their target muscles without any correct innervation at E12.5, indicating axon guidance defects


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory