About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6140058
Allelic
Composition
Lrch1em1Hwa/Lrch1em1Hwa
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrch1em1Hwa mutation (0 available); any Lrch1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice

hematopoietic system
• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice

immune system
N
• populations of CD4+ cells in spleen and lymph nodes (LNs)
• numbers of CD4+ T cells in spleen and draining LNs during induction of EAE with MOG same as in similarly treated wild-type mice
• TCR usage in CD4+ T cells during induction of EAE with MOG same as in similarly treated wild-type mice
• CD4+ T cell proliferation and Il2, Cd44 and Cd25 expression during induction of EAE with MOG same as in similarly treated wild-type mice
• increased migration of encephalitogenic CD4+ T cells from MOG-treated mice into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated WT mice
• MOG (35-55) peptide-induced EAE
• encephalitogenic CD4+ T cells from MOG-treated mice cause earlier disease onset with higher clinical scores when transplanted into sub-lethally irradiated WT recipient mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
J:238772


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/03/2022
MGI 6.21
The Jackson Laboratory