Phenotypes Associated with This Genotype

Genotype
MGI:6113845

• Allelic Composition: Gatm^m1Btlr/Gatm^m1Btlr
• Genetic Background: C57BL/6J-Gatm^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:252049 )

• in DSS-treated mice

digestive/alimentary system

increased enterocyte apoptosis ( J:252049 )

• in the colon of DSS-treated mice

diarrhea ( J:252049 )

• increased in DSS-treated mice

abnormal duodenum crypts of Lieberkuhn morphology ( J:252049 )

• the colons of the DSS-treated mice exhibit loss of crypt architecture, a denuded epithelial layer, and prominent inflammatory infiltrates compared with wild-type mice

decreased colon length ( J:252049 )

• in DSS-treated mice

increased susceptibility to induced colitis ( J:252049 )

• DSS-treated mice exhibit severe muscle wasting, increased weight loss, decreased creatine levels in intestinal epithelium, increased intestinal epithelium permeability, increased colon shortening, diarrhea, rectal bleeding, excessive cell death in the colon and increased mortality compared with wild-type mice

• however, supplementation with creatine reverses muscle wasting and restores body weight while not ameliorating normal DSS-induced colitis

growth/size/body

increased susceptibility to weight loss ( J:252049 )

• in DSS-treated mice

• however, supplementation with creatine reverses muscle wasting and restores body weight

homeostasis/metabolism

decreased creatine level ( J:252049 )

• in the intestinal epithelium of DSS-treated mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:252049 )

• in DSS-treated mice

immune system

increased susceptibility to induced colitis ( J:252049 )

• DSS-treated mice exhibit severe muscle wasting, increased weight loss, decreased creatine levels in intestinal epithelium, increased intestinal epithelium permeability, increased colon shortening, diarrhea, rectal bleeding, excessive cell death in the colon and increased mortality compared with wild-type mice

• however, supplementation with creatine reverses muscle wasting and restores body weight while not ameliorating normal DSS-induced colitis

cellular

increased enterocyte apoptosis ( J:252049 )

• in the colon of DSS-treated mice

endocrine/exocrine glands

abnormal duodenum crypts of Lieberkuhn morphology ( J:252049 )

• the colons of the DSS-treated mice exhibit loss of crypt architecture, a denuded epithelial layer, and prominent inflammatory infiltrates compared with wild-type mice