Phenotypes Associated with This Genotype

Genotype
MGI:6098754

• Allelic Composition: Mecp2^tm2Bird/Y
• Genetic Background: B6.129P2-Mecp2^tm2Bird/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heartbeat ( J:241788 )

♂ • irregular heart rhythm with sudden bradycardic events

abnormal heart rate ( J:241788 )

♂ • abnormal fluctuations in heart rate in mice that die suddenly

increased heart rate variability ( J:241788 )

♂ • increase in heart rate variability during the dark cycle

decreased heart rate ( J:241788 )

♂ • heart rate declines dramatically to severe bradycardia before death

ventricular premature beat ( J:241788 )

♂ • mice exhibit a higher incidence of sinus pauses and premature ventricular contractions

atrioventricular block ( J:241788 )

♂ • an increase in sinus pauses and atrioventricular block events are seen up until 13 hours before death, but once heart rate drops to the bradycardic level, these arrhythmias cease

prolonged QT interval ( J:241788 )

♂

increased response of heart to induced stress ( J:241788 )

♂ • mice show increased susceptibility to induction of arrhythmias

homeostasis/metabolism

increased response of heart to induced stress ( J:241788 )

♂ • mice show increased susceptibility to induction of arrhythmias

decreased body temperature ( J:241788 )

♂ • decreased body temperature during both the light and dark cycle

mortality/aging

premature death ( J:241788 )

♂ • 2 of 7 mice exhibit sudden death

♂ • mice die prematurely with a median survival of 16 weeks

respiratory system

abnormal respiration ( J:241788 )

♂ • abnormal hypoxic breathing response

apnea ( J:241788 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:241788