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Phenotypes Associated with This Genotype
Genotype
MGI:6095193
Allelic
Composition
Tg(Prnp-TARDBP*Q331K)103Dwc/0
Genetic
Background
B6N.Cg-Tg(Prnp-TARDBP*Q331K)103Dwc/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-TARDBP*Q331K)103Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• induction of glutathione levels in response to sodium arsenite is impaired in primary astrocyte cultures and mice show an increase in transcripts of the antioxidant genes Hmox1 and Nqo1in the spinal cord, indicating elevated oxidative stress and impaired antioxidant response

nervous system
• loss of insoluble heterogeneous nuclear ribonucleoprotein K in the brain

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 10 DOID:0060201 OMIM:612069
J:242322


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory