Phenotypes Associated with This Genotype

Genotype
MGI:6093470

• Allelic Composition: Ccn6^tm1.1Cgkl/Ccn6^tm1.1Cgkl; Tg(MMTV-cre)1Mam/0
• Genetic Background: FVB/N-Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:241259 )

♀ • 16 week old adult virgin mice show a reduction in mammary gland complexity

♀ • mammary glands exhibit reduced mitosis

♀ • the non-neoplastic mammary gland tissues show a variety of abnormalities including persistent terminal end buds, secretory hyperplasia, and atypical ductal hyperplasia

abnormal involution of the mammary gland ( J:241259 )

♀ • abnormal age-related involution in virgin mice, with all mice at 8 months of age showing residual brown adipose tissue in the mammary glands and terminal end buds that persist in 66.7% of these mice

♀ • however, dams are able to nurse litters and glands undergo post-lactational involution

abnormal mammary gland duct morphology ( J:241259 )

♀ • hypoplastic ductal epithelium with reduced ductal thickness in 16 week old virgin mice

♀ • ductal epithelial cells are flat instead of tall columnar

abnormal mammary duct terminal end bud morphology ( J:241259 )

♀ • pre-pubertal (5 week) and pubertal (8 week) mice exhibit reduced numbers of terminal end buds and of bifurcated terminal end buds

♀ • persistent terminal end buds are seen in the non-neoplastic mammary gland tissues

mammary gland duct hyperplasia ( J:241259 )

♀ • atypical ductal hyperplasia is seen in the non-neoplastic mammary gland tissues

increased mammary adenocarcinoma incidence ( J:241259 )

♀ • 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months

♀ • mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas

♀ • tumors are highly invasive into the surrounding mammary tissues and skeletal muscle

integument

abnormal mammary gland morphology ( J:241259 )

♀ • 16 week old adult virgin mice show a reduction in mammary gland complexity

♀ • mammary glands exhibit reduced mitosis

♀ • the non-neoplastic mammary gland tissues show a variety of abnormalities including persistent terminal end buds, secretory hyperplasia, and atypical ductal hyperplasia

abnormal involution of the mammary gland ( J:241259 )

♀ • abnormal age-related involution in virgin mice, with all mice at 8 months of age showing residual brown adipose tissue in the mammary glands and terminal end buds that persist in 66.7% of these mice

♀ • however, dams are able to nurse litters and glands undergo post-lactational involution

abnormal mammary gland duct morphology ( J:241259 )

♀ • hypoplastic ductal epithelium with reduced ductal thickness in 16 week old virgin mice

♀ • ductal epithelial cells are flat instead of tall columnar

abnormal mammary duct terminal end bud morphology ( J:241259 )

♀ • pre-pubertal (5 week) and pubertal (8 week) mice exhibit reduced numbers of terminal end buds and of bifurcated terminal end buds

♀ • persistent terminal end buds are seen in the non-neoplastic mammary gland tissues

mammary gland duct hyperplasia ( J:241259 )

♀ • atypical ductal hyperplasia is seen in the non-neoplastic mammary gland tissues

increased mammary adenocarcinoma incidence ( J:241259 )

♀ • 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months

♀ • mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas

♀ • tumors are highly invasive into the surrounding mammary tissues and skeletal muscle

neoplasm

increased mammary adenocarcinoma incidence ( J:241259 )

♀ • 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months

♀ • mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas

♀ • tumors are highly invasive into the surrounding mammary tissues and skeletal muscle

increased metastatic potential ( J:241259 )

♀ • distant metastasis develop in 46.2% of tumor-bearing mice, mainly to the lungs and in once case the soft tissues of the neck

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast metaplastic carcinoma		DOID:4680		J:241259