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Phenotypes Associated with This Genotype
Genotype
MGI:5912375
Allelic
Composition
KitW/KitW
Genetic
Background
B6.Cg-KitW/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW mutation (10 available); any Kit mutation (180 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• weights are normal at embryonic day 16 but by birth the body weight is retarded behind that of wildtype siblings

hematopoietic system
• identified as early as embryonic day 16, the earliest timepoint assessed, and the severity is greatest in W/W homozygotes compared with homozygotes for the viable dominant spotting allele or compound heterozgyotes

mortality/aging
• heterozygous intercrosses produce only 14.5% homozygotes instead of the 25% expected, one sixth of which are born dead or die perinatally and nearly all the remainder die by 3 days of age, without postnatal growth

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
macrocytic anemia DOID:2361 J:243758


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory