Phenotypes Associated with This Genotype

Genotype
MGI:5912373

• Allelic Composition: Lrfn3^{tm1(KOMP)Vlcg}/Lrfn3^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6J * C57BL/6NTac
• Cell Lines: 15252A-A12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:241274 )

N • mice exhibit normal gross morphology and neuronal density in the hippocampus

abnormal synapse morphology ( J:241274 )

• increased excitatory and inhibitory synapse density

• however, thickness and perforation are normal and re-expression of the endogenous gene rescues excitatory synapse numbers

abnormal postsynaptic density morphology ( J:241274 )

• increased in the density and length of postsynaptic density apposed to presynaptic vesicle

increased miniature excitatory postsynaptic current frequency ( J:241274 )

• increased mEPSC frequency but not amplitude

• however, frequency is rescued by re-expression of the endogenous gene

increased miniature inhibitory postsynaptic current frequency ( J:241274 )

• increased mIPSC frequency but not amplitude

• however, re-expression of the endogenous gene does not rescue mIPSC frequency