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Phenotypes Associated with This Genotype
Genotype
MGI:5912041
Allelic
Composition
Destm1Cba/Destm1Cba
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Destm1Cba mutation (1 available); any Des mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

cardiovascular system
• left ventricle wall thickness at optimal volume is increased
• deposits of collagen in the right ventricle, left ventricle, and interventricular septum indicating cardiac fibrosis
• larger deposits of collagen are seen in calcified regions
• heart exhibits calcifications in the cardiac wall in most mice
• developed pressure, rate of pressure increase, and developed wall stress are reduced, suggesting that active force generation of the contractile apparatus is reduced
• heart exhibits lower developed pressure
• lower developed pressure is associated with a lower rate of pressure change (dP/dt) during the rising and falling phases of contraction
• heart exhibits increased diastolic pressures at all filling volumes
• active stress generated at maximal calcium concentration is lower in isolated skinned trabecular muscle
• the active force during the contraction of maximal calcium concentration at the end of the determination of calcium-sensitivity is slightly lower in isolated skinned trabecular muscle
• however, the calcium-sensitivity of force is unchanged

muscle
• developed pressure, rate of pressure increase, and developed wall stress are reduced, suggesting that active force generation of the contractile apparatus is reduced

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiomyopathy DOID:0050700 J:130557


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory