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Phenotypes Associated with This Genotype
Genotype
MGI:5910053
Allelic
Composition
Tg(Myh6-TNNT2*I79N)8Jdp/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice challenged with isoproterenol exhibit altered cardiac gap junctions
• rapid pacing of isolated hearts induces changes in connexin 43 protein expression, solubility, and isoform distribution and results in accumulation of dephosphorylated connexin 43 isoform P0 in cardiac tissue
• cardiac tissue after isoproterenol challenge shows a reduction in junctional connexin 43 and regions of connexin 43 isoform P0 accumulation
• small decrease in heart weight to body weight ratio
• mice do not exhibit cardiac hypertrophy
• rapid pacing of isolated hearts increases anisotropy ratio, with transverse conduction velocity reduced by more than 20%
• after rapid pacing challenge, the myocardium, in areas of connexin 43 isoform P0 accumulation, is energetically compromised as indicated by an increase in activated AMP-dependent kinase in these areas resulting in ATP depletion
• following pacing, Lucifer yellow dye spread through intact cardiomyocytes is reduced indicating reduced gap junctional intercellular coupling
• 25% of mice challenged with the catecholamine isoproterenol exhibit ventricular tachycardia
• rapid pacing of isolated hearts induces ventricular tachycardia in more than 50% of mice
• 56% of mice challenged with the catecholamine isoproterenol exhibit ventricular ectopy
• mice treated with isoproterenol exhibit progressive prolongation of QRS duration
• rapid pacing of isolated hearts causes progressive QRS prolongation
• papillary muscle fibers exhibit increased calcium sensitivity of steady state force development in both sedentary and exercised groups
• maximal steady state force developed by muscle fibers is decreased in both sedentary and exercised groups
• muscle fibers show an increased rate of force activation and moderately increased rate of relaxation
• cardiac muscle is less sensitive to acidic pH and shows a smaller decrease in calcium-sensitivity of force development indicating a loss of sensitivity to pH-induced shifts in calcium dependence of force
• large increase in the calcium sensitivity of the ATPase activity and force development in skinned fibers

mortality/aging
N
• mice exhibit normal survival and chronic swimming exercises do not affect survival

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 2 DOID:0110308 OMIM:115195
J:213305


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory