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Phenotypes Associated with This Genotype
Genotype
MGI:5909258
Allelic
Composition
Tg(Myh6-MYL3*A57G)#Dsc/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• increase in size of cardiomyocytes
• heart-to-body weight ratio is increased
• decrease in number of nuclei indicating cardiac hypertrophy
• left ventricular volumes in diastole and systole are larger, indicating development of eccentric hypertrophy
• left ventricle exhibits myofilament disarray and signs of fibrosis
• left ventricle exhibits signs of fibrosis (J:178377)
• however, hearts exhibit normal size in 10-12 month old males (J:178377)
• hearts exhibit severe fibrosis as early as 6 months of age (J:202154)
• during inferior vena cava occlusion, the load-independent end-systolic elastance is higher compare to controls
• stroke work is increased
• increase in left ventricular end diastolic volume with higher left ventricular end systolic pressure, indicating higher heart contractility
• echocardiography shows larger left ventricular volumes in diastole and systole, however left ventricle posterior wall and anterior wall dimensions are normal
• higher left ventricular end systolic pressure
• muscle fibers exhibit increased stiffness (J:178377)
• skinned papillary muscle show a 20-35% decrease in maximal tension (J:202154)
• papillary muscle shows a small, but significant, increase in the calcium sensitivity of force (J:202154)
• level of passive tension is increased in skinned papillary muscle, suggesting higher stiffness (increased resistance to stretch) in the myocardium (J:202154)

muscle
• increase in left ventricular end diastolic volume with higher left ventricular end systolic pressure, indicating higher heart contractility
• papillary muscle fibers show a change in the interfilament spacing in rigor, with the lattice spacing being reduced in the myocardium
• however, no alterations in actomyosin cross-bridge mass distribution are seen
• increase in size of cardiomyocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 8 DOID:0110314 OMIM:608751
J:202154


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/17/2018
MGI 6.11
The Jackson Laboratory