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Phenotypes Associated with This Genotype
Genotype
MGI:5908986
Allelic
Composition
Tg(Myh6-Tnnt2*R92L)1Jcf/0
Genetic
Background
B6.Cg-Tg(Myh6-Tnnt2*R92L)1Jcf
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• adult hearts show myocyte disarray and degeneration, mild inflammatory cell infiltration, occasional hypertrophied cells, and minimal fibrosis
• isolated myofilament lysis and discontinuity in adult ventricular myocytes
• adult hearts show myocyte degeneration
• severe biatrial enlargement
• ventricular mass is increased by 8-9% in 6 month old mice
• hearts exhibit impaired systolic performance at baseline and with inotropic challenge
• diastolic function, as indicated by increases in end-diastolic pressure and decreases in the rate of relaxation, is impaired
• left ventricular systolic pressure and the rate of pressure development (+dP/dt) are lower in response to increasing calcium concentrations
• cardiomyopathy characterized by severe biatrial enlargement and decrease in ventricular compliance
• mice do not exhibit induction of the hypertrophic gene program until late adulthood (about 10 months) and late remodeling, indicating development of a late onset, mild to moderate concentric hypertrophy

muscle
• isolated myofilament lysis and discontinuity in adult ventricular myocytes
• adult hearts show myocyte degeneration
• hearts exhibit impaired systolic performance at baseline and with inotropic challenge
• diastolic function, as indicated by increases in end-diastolic pressure and decreases in the rate of relaxation, is impaired
• cardiomyopathy characterized by severe biatrial enlargement and decrease in ventricular compliance
• mice do not exhibit induction of the hypertrophic gene program until late adulthood (about 10 months) and late remodeling, indicating development of a late onset, mild to moderate concentric hypertrophy

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy 2 DOID:0110308 OMIM:115195
J:104369


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/18/2019
MGI 6.14
The Jackson Laboratory