Phenotypes Associated with This Genotype

Genotype
MGI:5908453

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Gt(ROSA)26Sor^{tm2(CARD11*L225LI)Jrld}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:228288 )

• all die by P6

neoplasm

increased B cell derived lymphoma incidence ( J:228288 )

• blastoid cells that infiltrate solid organs are seen indicating high-grade lymphoma

• blastoid B cells express low levels of IL7 or CD25 indicating the disease does not resemble acute B-cell lineage leukemia

immune system

increased B cell number ( J:228288 )

increased plasma cell number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal plasmablast number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal spleen morphology ( J:228288 )

• spleens contain homogenous populations of large cells with prominent nucleoli and high proliferation indices

enlarged spleen ( J:228288 )

• massive

spleen hyperplasia ( J:228288 )

• high proliferation indices

abnormal B cell activation ( J:228288 )

• recombined B cells exhibit an activated phenotype with high CD80 and Sca-1 expression and elevated CD43 levels

increased B cell proliferation ( J:228288 )

• B cells proliferate vigorously in the absence of any specific B cell survival or mitogenic factors for at least 10 days in culture

• high proliferation indices in the spleen

enlarged lymph nodes ( J:228288 )

hematopoietic system

abnormal bone marrow cell number ( J:228288 )

• massive reduction in the B220+ IgM- compartment in the bone marrow indicating infiltration by peripheral blastoid B cells

increased B cell number ( J:228288 )

increased plasma cell number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal plasmablast number ( J:228288 )

• B cells in the spleen and bone marrow are CD138+ B220^int or CD138+ B220^low indicating these consist of plasmablasts and plasma cells

abnormal spleen morphology ( J:228288 )

• spleens contain homogenous populations of large cells with prominent nucleoli and high proliferation indices

enlarged spleen ( J:228288 )

• massive

spleen hyperplasia ( J:228288 )

• high proliferation indices

abnormal B cell activation ( J:228288 )

• recombined B cells exhibit an activated phenotype with high CD80 and Sca-1 expression and elevated CD43 levels

increased B cell proliferation ( J:228288 )

• B cells proliferate vigorously in the absence of any specific B cell survival or mitogenic factors for at least 10 days in culture

• high proliferation indices in the spleen

cellular

increased B cell proliferation ( J:228288 )

• B cells proliferate vigorously in the absence of any specific B cell survival or mitogenic factors for at least 10 days in culture

• high proliferation indices in the spleen

growth/size/body

enlarged spleen ( J:228288 )

• massive

spleen hyperplasia ( J:228288 )

• high proliferation indices

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diffuse large B-cell lymphoma		DOID:0050745		J:228288