Phenotypes for Tg(HBx-HCV)C5Tto MGI:5907647 MGI Mouse

abnormal cardiac muscle tissue morphology ( J:105313 )

• myofiber disorganization and disarray

• disarray of myofibers, scarcity of myofibrils, vacuolization and pleomorphic nuclear changes are seen in hearts at 12 months of age

• hearts exhibit increased number of bizarre-shaped mitochondria, aggregation of mitochondria, and cavity formation of mitochondria

• however, no infiltration of lymphocytes is seen at 6, 9, or 12 months of age, indicating no myocarditis

abnormal myocardial fiber morphology ( J:105313 )

• cardiomyocytes exhibit irregular shaped nuclei and myofilament loss

increased myocardial fiber size ( J:105313 )

• hypertrophy of cardiomyocytes at 12 months of age

• cardiomyocyte cross-sectional area is larger

dilated heart left ventricle ( J:105313 )

• the left ventricular cavity is larger

abnormal heart ventricles weight ( J:105313 )

• ventricular weight-to-body weight ratio is higher at 12 months of age

cardiac fibrosis ( J:105313 )

decreased cardiac muscle contractility ( J:105313 )

• mice exhibit decreased fraction shortening and ejection fraction at 12 weeks of age

• however, heart rate and blood pressure are normal

abnormal heart echocardiography feature ( J:105313 )

• mice exhibit increased left ventricular end-diastolic and end-systolic dimension, decreased fractional shortening and ejection fraction, increased E wave/A wave velocity ratio at 12 months of age

cardiomyopathy ( J:105313 )

abnormal mitochondrial shape ( J:105313 )

• hearts show increased number of bizarre-shaped mitochondria