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Phenotypes Associated with This Genotype
Genotype
MGI:5907647
Allelic
Composition
Tg(HBx-HCV)C5Tto/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• myofiber disorganization and disarray
• disarray of myofibers, scarcity of myofibrils, vacuolization and pleomorphic nuclear changes are seen in hearts at 12 months of age
• hearts exhibit increased number of bizarre-shaped mitochondria, aggregation of mitochondria, and cavity formation of mitochondria
• however, no infiltration of lymphocytes is seen at 6, 9, or 12 months of age, indicating no myocarditis
• cardiomyocytes exhibit irregular shaped nuclei and myofilament loss
• hypertrophy of cardiomyocytes at 12 months of age
• cardiomyocyte cross-sectional area is larger
• the left ventricular cavity is larger
• ventricular weight-to-body weight ratio is higher at 12 months of age
• mice exhibit decreased fraction shortening and ejection fraction at 12 weeks of age
• however, heart rate and blood pressure are normal
• mice exhibit increased left ventricular end-diastolic and end-systolic dimension, decreased fractional shortening and ejection fraction, increased E wave/A wave velocity ratio at 12 months of age

cellular
• hearts show increased number of bizarre-shaped mitochondria

muscle
• myofiber disorganization and disarray
• cardiomyocytes exhibit irregular shaped nuclei and myofilament loss
• hypertrophy of cardiomyocytes at 12 months of age
• cardiomyocyte cross-sectional area is larger
• mice exhibit decreased fraction shortening and ejection fraction at 12 weeks of age
• however, heart rate and blood pressure are normal
• hearts show Z-band abnormalities

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiomyopathy DOID:0050700 J:105313


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory