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Phenotypes Associated with This Genotype
Genotype
MGI:5907465
Allelic
Composition
Lpltm1Bres/Lpl+
Tg(Myh6-LPL*)357Ijg/0
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpltm1Bres mutation (0 available); any Lpl mutation (29 available)
Tg(Myh6-LPL*)357Ijg mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 4 month old males exhibit enlarged hearts
• females exhibit an increase in heart weight

mortality/aging
• males begin to die after 20 weeks of age and all die by 60 weeks of age
• breeding females begin to die around 4 weeks of age and all die by 32 weeks of age

cardiovascular system
• disarrayed cardiomyocyte architecture with increased mitochondria
• increase in intracellular neutral lipid in hearts from 24-hour fasted mice
• 58.9% increase in cholesteryl ester and a 24.7% increase in free fatty acid in hearts
• lipid accumulation within myocytes
• 4 month old males exhibit enlarged hearts
• females exhibit an increase in heart weight
• hearts exhibit 54% more VLDL-triglyceride uptake in the absence of heparin and 26% more uptake in the presence of heparin than controls
• left ventricular systolic function is impaired
• however, no increase in ventricular wall thickness is seen

homeostasis/metabolism
• heparinized mice exhibit faster clearance of VLDL from the plasma than single Lpl homozygotes
• increase in intracellular neutral lipid in hearts from 24-hour fasted mice
• 24.7% increase in free fatty acid in hearts

muscle
• disarrayed cardiomyocyte architecture with increased mitochondria
• lipid accumulation within myocytes
• left ventricular systolic function is impaired
• however, no increase in ventricular wall thickness is seen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cardiomyopathy DOID:0050700 J:134550


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory