About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5907236
Allelic
Composition
Tg(Myh6-Htr2b)1Lum/0
Genetic
Background
involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6-Htr2b)1Lum mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• hearts show structural abnormalities along with mitochondrial proliferation in ventricular myocardium
• hearts exhibit lipid deposition
• cardiomyocytes exhibit T-tubule enlargement
• however, no myocardial apoptosis, fibrosis, or inflammatory cell infiltrates are seen
• cardiomyocytes exhibit a 23% increase in size
• heart shows 11% more cardiomyocytes than controls
• increase in left ventricle weight-to-body weight ratio by 178%
• increase in the number of cardiomyocytes and increase in size of cardiomyocytes with no loss of systolic performance, indicating compensated cardiac hypertrophy
• marker analysis indicates hypertrophic gene expression in hearts
• increase in the thickness of the left ventricular free wall in 12 week old males
• echocardiography indicates that posterior wall thickness and the total left ventricular mass are increased in 12 week old males
• however, left ventricular end-systolic or end-diastolic diameters, fractional shortening, or systolic blood pressures are not altered
• heart rate is slightly increased in 12 week old males

cellular
• mitochondria are rounded and irregular in hearts
• mitochondria are higher in number in hearts
• hearts show increased activity of succinate dehydrogenase and cytochrome C oxidase and decreased adenine nucleotide translocator protein expression, indicating increased respiratory chain and oxidative phosphorylation in the mitochondria
• hearts show increased mitochondrial proliferation in ventricular myocardium
• hearts show increased activity of succinate dehydrogenase and cytochrome C oxidase and decreased adenine nucleotide translocator protein expression, indicating increased respiratory chain and oxidative phosphorylation in the mitochondria

muscle
• cardiomyocytes exhibit T-tubule enlargement
• however, no myocardial apoptosis, fibrosis, or inflammatory cell infiltrates are seen
• cardiomyocytes exhibit a 23% increase in size
• heart shows 11% more cardiomyocytes than controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypertrophic cardiomyopathy DOID:11984 OMIM:PS192600
J:128784


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory