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Phenotypes Associated with This Genotype
Genotype
MGI:5906061
Allelic
Composition
Tg(Myh7-Phc1)#Yota/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 100% lethality within 8 months of age

cardiovascular system
• ventricles are occupied by abnormal cardiomyocytes at 3 and 6 months of age
• in the most severe regions, H lines are not visible
• thinning of the myocardium associated with cardiac failure
• hearts are enlarged with severe reduction of the ventricular wall thickness at autopsy
• however, hypertrophy of the heart is not seen at any stage
• left ventricular dimension is increased and left ventricular ejection fraction is decreased in 5-6 month old mice
• however, no reduction in left ventricular posterior wall thickness or interventricular septal thickness is seen at 5-6 months of age
• increase in cardiomyocyte apoptosis at 3 and 6 months of age
• mice show characteristics of heart failure such as general weakness, lack of food and water intake, labored breathing, generalized edema with gain of body weight

cellular
• increase in cardiomyocyte apoptosis at 3 and 6 months of age
• the number of the stacks of the mitochondrial cristae is reduced in cardiomyocytes
• very elongated mitochondria are sometimes seen in cardiomyocytes

homeostasis/metabolism
• intracavitary thrombi are frequently seen in the left atrium at autopsy
• death is preceded for several days by generalized edema

muscle
• ventricles are occupied by abnormal cardiomyocytes at 3 and 6 months of age
• in the most severe regions, H lines are not visible
• thinning of the myocardium associated with cardiac failure
• left ventricular dimension is increased and left ventricular ejection fraction is decreased in 5-6 month old mice
• however, no reduction in left ventricular posterior wall thickness or interventricular septal thickness is seen at 5-6 months of age
• increase in cardiomyocyte apoptosis at 3 and 6 months of age
• cardiomyocyte sarcomeres show abnormal arrangements with irregular and loose myofilaments
• in the most severe regions, M lines are not visible in cardiomyocytes
• Z-lines are vague and enlarged in cardiomyocytes

respiratory system
• death is preceded for several days by dyspnea

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:75968


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory