Phenotypes Associated with This Genotype

Genotype
MGI:5897011

• Allelic Composition: Dmd^tm1Kmf/Y
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:233298 )

• mild muscle force deficiency indicated by decreased grip strength

cellular

skeletal muscle fiber necrosis ( J:233298 )

• muscle shows signs of myofiber necrosis

growth/size/body

increased body weight ( J:233298 )

• mice weigh more than wild-type controls at 24 and 48 weeks of age, but show similar weight as Dmd^mdx mice

homeostasis/metabolism

increased circulating creatine kinase level ( J:233298 )

• serum creatine kinase levels at 3, 4, 8, and 12 weeks of age are elevated compared to wild-type mice but lower than in Dmd^mdx mice and are increases to a similar extent as in Dmd^mdx mice at 24 weeks of age

immune system

myositis ( J:233298 )

• muscle shows signs of mononuclear cell infiltration at 3 weeks, with central nucleation pronounced by 4 weeks indicating some myofiber regeneration

muscle

skeletal muscle fiber necrosis ( J:233298 )

• muscle shows signs of myofiber necrosis

myositis ( J:233298 )

• muscle shows signs of mononuclear cell infiltration at 3 weeks, with central nucleation pronounced by 4 weeks indicating some myofiber regeneration

skeletal muscle fibrosis ( J:233298 )

• marked diaphragm fibrosis is seen by 6 months

dystrophic muscle ( J:233298 )

muscle degeneration ( J:233298 )

• progressive muscle degeneration, with muscles showing widespread necrosis, extensive inflammation and increased number of regenerative fibers at 6 and 12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:233298