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Phenotypes Associated with This Genotype
Genotype
MGI:5883282
Allelic
Composition
Shank3tm1Cmpl/Shank3tm1Cmpl
Genetic
Background
B6J.129S6-Shank3tm1Cmpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm1Cmpl mutation (0 available); any Shank3 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impaired motor learning on the accelerating rotarod, showing shorter latencies to fall from the rotard and showing little to no improvement in motor learning
• however, mice do not exhibit anxiety-like phenotypes in the open field, elevated plus maze, or dark/light task, do not show social interaction deficits and do not exhibit excessive grooming
• mice exhibit decreased locomotor activity in response to novel environments
• in the first 5 min of a novel home cage, mice show a decrease in locomotor activity that reverts to wild-type level rapidly thereafter
• distance traveled in the open field over 10 min is decreased
• distance traveled in the elevated plus maze over 5 min is decreased
• total number of photobeams interrupted during the 10 min in the dark/light chamber is decreased
• although mice do show a strong increase in latency to enter the brightly lit side of the dark/light box, there is no difference in the total time spent in either dark or light side of the chamber indicating that mice show an avoidance of the novel, brightly lit chamber initially
• mice are slower the learn the water maze but show use of spatial strategy during subsequent recall
• however, mice have a higher swim speed during training in the Morris water maze than controls
• mice exhibit avoidance behavior toward inanimate objects; in the marble burying task, mice show little or no interest in burying marbles and often leave them undisturbed and in the nest building task, when a nestlet was added to a novel cage following habituation, mice show very little change in their nestlets
• mice exhibit impaired motor coordination on the accelerating rotarod, showing shorter latencies to fall from the rotarod

growth/size/body

nervous system
• hippocampal synaptic plasticity is impaired
• basal hippocampal synaptic transmission, in the absence of synaptic plasticity, is impaired
• however, no changes are seen in presynaptic function or short-term plasticity
• decrease in fEPSP slope
• mean frequency of mEPSCs onto CA1 neurons in the presence of TTX is decreased and is reflected in the rightward shift in the distribution of interevent frequency indicating longer periods between mEPSCs
• mice show a decrease in the magnitude of post-tetanic potentiation in the first 5 min following the conditioning stimulus in the hippocampus
• however, LTP is not affected
• mice exhibit a decrease in the magnitude of mGluR-long term depression at 55-60 min after DHPG application


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/05/2019
MGI 6.13
The Jackson Laboratory