About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5883140
Allelic
Composition
Tg(Myh6-Pln*R9C)#Ces/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

mortality/aging
• mice die on average at 20.9 weeks of age, with survival ranging between 12 and 35 weeks

cardiovascular system
• myocyte enlargement without disarray
• prominent left atria
• biventricular cardiac dilation begins at 4 months of age
• massive left ventricular dilation
• extensive interstitial fibrosis
• dilated cardiomyopathy rapidly progresses
• mice develop diminished left ventricle contractility as heart chamber size increases
• the decay in calcium transients is prolonged in myocytes
• myocyte relaxation is delayed
• however, SR calcium-release velocities, time to 90% peak calcium signal and cell shortening velocities are similar to wild-type
• beta-adrenergic stimulation does not normalize the depressed calcium kinetics
• mice show symptoms of terminal heart failure including dyspnea, lethargy, and peripheral cyanosis

behavior/neurological
• mice eventually show symptoms of terminal heart failure including lethargy

homeostasis/metabolism
• mice eventually show symptoms of terminal heart failure including terminal cyanosis

liver/biliary system

muscle
• myocyte enlargement without disarray
• dilated cardiomyopathy rapidly progresses
• mice develop diminished left ventricle contractility as heart chamber size increases

respiratory system
• mice eventually show symptoms of terminal heart failure including dyspnea

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy 1P DOID:0110439 OMIM:609909
J:82353


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/23/2021
MGI 6.16
The Jackson Laboratory