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Phenotypes Associated with This Genotype
Genotype
MGI:5882084
Allelic
Composition
Nkx2-5tm3.1Mwc/Nkx2-5+
Genetic
Background
B6J.Cg-Nkx2-5tm3.1Mwc/Mwc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5tm3.1Mwc mutation (0 available); any Nkx2-5 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• E18.5 heart shows increased pulmonary artery diameter, but no abnormality in aortic diameter
• right ventricular dysmorphism with a shift to the base, rounded apex, and misalignment relative to the left ventricle
• highly dysmorphic appearance of atrioventricular node region in heterozygotes
• 12% show atrial septal defects, which are not found in control or I183M mutant heterozygotes
• in 88% of heterozgyous adults
• at 15 weeks of age the right ventricle displays a shift to the base with a rounded apex relative to controls
• significant decrease in right ventricle ejection fraction
• under homeostatic nonanesthetized conditions there is increased PQ and QRS and a small tendency for decreased ST intervals, and 3 of 8 heterozygotes showed possible split QRS waves
• small tendency for decreased ST interval
• neonatal cardiomyocytes show a decrease in basal and maximal respiration compared with control cardiomyocytes

muscle
• highly dysmorphic appearance of atrioventricular node region in heterozygotes
• significant decrease in right ventricle ejection fraction


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory