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Phenotypes Associated with This Genotype
Genotype
MGI:5827840
Allelic
Composition
Bmpr2tm1Mmue/Bmpr2+
Genetic
Background
B6.129S1-Bmpr2tm1Mmue
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Mmue mutation (0 available); any Bmpr2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 6 month old mice exhibit enhanced muscularization of peripheral pulmonary arteries in the lung
• treatment with BMP9 prevents vascular leak to a similar degree as in wild-type mice
• mice injected with LPS develop increased pulmonary vascular leak compared to wild-type mice
• monolayers of pulmonary endothelial cells in vitro show increased permeability at baseline and following LPS stimulation
• mice exhibit normal right ventricular systolic pressure at 3 months of age but develop elevated right ventricular systolic pressure by 6 months of age
• however, mice do not exhibit right ventricular hypertrophy and show no differences in left ventricular end diastolic pressure or cardiac output at 6 months
• mice exhibit pulmonary arterial hypertension by 6 months of age
• treatment of 6 month old mice with daily intraperitoneal injection of BMP9 for 4 weeks reverses all indices of pulmonary arterial hypertension, returning right ventricular systolic pressure to normal and reversing the enhanced pulmonary arterial muscularization


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory