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Phenotypes Associated with This Genotype
Genotype
MGI:5806505
Allelic
Composition
Tg(SFTPC-CD74/ROS1)125Tno/0
Genetic
Background
C57BL/6J-Tg(SFTPC-CD74/ROS1)125Tno
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SFTPC-CD74/ROS1)125Tno mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die by 50 weeks of age

neoplasm
• lepidic growth of the alveolar walls and papillary nodules are seen as early as 3.4 weeks of age
• multiple nodules are seen in the lungs and mice show rapid tumor progression
• mice treated with crizotinib or ASP3026 show reduced tumor burden, reduced thickness of alveolar walls and suppression of tumor nodules
• mice show development of multiple lung adenoma
• lung tumors show similarity to human ROS1-fusion non-small cell lung cancer
• mice show development of adenocarcinoma-like nodules and lepidic lesions in the lungs

respiratory system
• lepidic growth of the alveolar walls and papillary nodules are seen as early as 3.4 weeks of age
• multiple nodules are seen in the lungs and mice show rapid tumor progression
• mice treated with crizotinib or ASP3026 show reduced tumor burden, reduced thickness of alveolar walls and suppression of tumor nodules
• mice show development of multiple lung adenoma
• lung tumors show similarity to human ROS1-fusion non-small cell lung cancer
• mice show development of adenocarcinoma-like nodules and lepidic lesions in the lungs

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
J:231770


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory