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Phenotypes Associated with This Genotype
Genotype
MGI:5804115
Allelic
Composition
Tg(Mafg-Nfe2l1)1Mym/0
Genetic
Background
involves: C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mafg-Nfe2l1)1Mym mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• lower body weight than wild-type mice by 7 weeks of age when fed a regular diet
• mice fed a high-fat diet beginning at 6 weeks of age exhibit a lower body weight than high-fat diet fed wild-type mice

homeostasis/metabolism
• plasma beta-hydroxybutyrate levels of high fat diet fed mice is higher than in wild-type mice
• plasma ammonia levels are decreased in both normal diet and high fat diet fed mice
• the liver of high-fat diet fed mice exhibits increased pyruvate, acetyl coenzyme A, citrate, and isocitrate levels and decreased lactate levels
• blood glucose level is increased in mice fed a normal diet
• mice fed a high-fat diet exhibit highly increased blood glucose levels compared to wild-type mice fed the same diet which show a mild increase in blood glucose levels
• plasma insulin level is increased in mice fed a normal diet
• both normal diet and high-fat diet fed mice show higher blood glucose levels after insulin injection compared to wild-type mice, indicating insulin resistance
• mice fed a high-fat diet develop diabetes mellitus

endocrine/exocrine glands
• the insulin-positive area in pancreatic sections is increased, suggesting constitutively activated insulin secretion
• islets are larger in mice fed a regular diet

liver/biliary system
• increase is liver tissue weight in mice fed a normal diet which is further enhanced on a high-fat diet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory