Phenotypes Associated with This Genotype

Genotype
MGI:5804108

• Allelic Composition: Ccar2^tm1Dac/Ccar2^tm1Dac
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:228688 )

• increase in body fat content beginning at puberty

behavior/neurological

decreased locomotor activity ( J:228688 )

• decrease in locomotor activity

growth/size/body

increased susceptibility to weight gain ( J:228688 )

• mice gain more weight than controls at thermos neutrality (32-33 degrees Celcius)

increased susceptibility to diet-induced obesity ( J:228688 )

• mice fed a high-fat diet exhibit increased body weight and body fat content

• high-fat diet fed mice treated with the Scd1 inhibitor A939572 show normalization of body weight gain and abnormal body composition

homeostasis/metabolism

increased circulating insulin level ( J:228688 )

• increase in circulating insulin levels

• high-fat diet fed mice exhibit higher insulin levels

decreased energy expenditure ( J:228688 )

increased susceptibility to diet-induced obesity ( J:228688 )

• mice fed a high-fat diet exhibit increased body weight and body fat content

• high-fat diet fed mice treated with the Scd1 inhibitor A939572 show normalization of body weight gain and abnormal body composition

decreased oxygen consumption ( J:228688 )

• decrease in energy expenditure

• however, mice show normal food intake and respiratory exchange ratios

impaired glucose tolerance ( J:228688 )

• mice develop impaired tolerance to an intraperitoneal glucose load as early as 16 weeks after birth and remain glucose intolerant throughout life

• high-fat diet further impairs glucose tolerance

• mice treated with the Scd1 inhibitor A939572 show improved glucose tolerance

increased hepatic glucose production ( J:228688 )

• during hyperinsulinemic-euglycemic clamps, mice show similar rates of glucose infusion and disposal but increased basal hepatic glucose production

• glucose production by primary hepatocytes is increased by about 50%

insulin resistance ( J:228688 )

• high-fat diet fed mice exhibit impaired insulin sensitivity

increased unsaturated fatty acids level ( J:228688 )

• monounsaturated fatty acid content (C18:1) is increased in livers

• mice treated with the Scd1 inhibitor A939572 show normalization of monounsaturated fatty acid content in the liver

neoplasm

neoplasm ( J:228688 )

N • spontaneous tumors arise in aging mice at the same rate as in wild-type controls