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Phenotypes Associated with This Genotype
Genotype
MGI:5803980
Allelic
Composition
Tg(Dct-Grm1)ESzc/0
Genetic
Background
C57BL/6J-Tg(Dct-Grm1)ESzc
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop spontaneous uveal melanoma by 8 months of age, with eyes showing ciliary body tumors with adjacent infiltration of the sclera by melanocytes
• melanocytic tumors are localized at the basis of the pars plicata of the ciliary body
• 2 of 6 eyes show tumor infiltration into the vitreous body

cellular
• mild to severe uveal melanocytic proliferation

pigmentation
• mild to severe uveal melanocytic proliferation
• 7-8 month old eyes exhibit accumulation of melanocytes in the optic choroid, the iris, the optic nerve, the outer segments of photoreceptors, and in the surrounding of the episcleral veins and invasion into the episcleral veins and into the trabecular meshwork

vision/eye
• mice develop spontaneous uveal melanoma by 8 months of age, with eyes showing ciliary body tumors with adjacent infiltration of the sclera by melanocytes
• melanocytic tumors are localized at the basis of the pars plicata of the ciliary body
• 2 of 6 eyes show tumor infiltration into the vitreous body
• remaining ciliary body is atrophic
• all eyes have anterior synechia between the iris and the cornea, resulting in a closure of the chamber angle
• retina is degenerated in the inner nuclear layer and/or the outer nuclear layer in eyes that show tumor infiltration into the vitreous body
• retina is focally detached in eyes that show tumor infiltration into the vitreous body
• mice at 7-8 months of age show thickening of the choroid with numerous atypical melanocytes
• thickened choroids are due to melanocytic proliferation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
uveal melanoma DOID:6039 OMIM:155720
OMIM:606660
OMIM:606661
J:230115


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/07/2017
MGI 6.11
The Jackson Laboratory