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Phenotypes Associated with This Genotype
Genotype
MGI:5796170
Allelic
Composition
Tg(Bglap2-TAg)1Rkho/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice survive to 26 weeks of age

neoplasm
• mice develop aggressive osteosarcoma with complete penetrance
• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold

skeleton
• mice develop aggressive osteosarcoma with complete penetrance
• treatment of mice with RANK-Fc beginning at 17 weeks of age suppresses osteosarcoma progression and reduces lung metastasis by more than 3-fold

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteosarcoma DOID:3347 OMIM:259500
J:234128


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory