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Phenotypes Associated with This Genotype
Genotype
MGI:5795582
Allelic
Composition
Psen1tm1Tak/Psen1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Tak mutation (0 available); any Psen1 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show increased levels of amyloid beta(1-42) peptide, however amyloid beta fails to deposit in the brains
• some hippocampal neurons exhibit Congo red birefringence and Thioflavin T reactivity, indicating neurofibrillary tangles
• mice exhibit formation of tau inclusions starting at 7 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Alzheimer's disease 3 DOID:0110042 OMIM:607822
J:108326


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory