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Phenotypes Associated with This Genotype
Genotype
MGI:5792957
Allelic
Composition
Tg(Alb1-Myc)#Sst/0
Tg(MtTGFA)Lmb/0
Genetic
Background
involves: C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• hepatocarcinogenesis progresses from early (3 weeks) and severe hepatocyte dysplasia (3 months) to preneoplastic focal lesions and hepatocellular carcinoma within 4 months
• by 9 months, more than 90% of mice develop hepatocellular carcinoma

hematopoietic system
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

immune system
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

liver/biliary system
• hepatocarcinogenesis progresses from early (3 weeks) and severe hepatocyte dysplasia (3 months) to preneoplastic focal lesions and hepatocellular carcinoma within 4 months
• by 9 months, more than 90% of mice develop hepatocellular carcinoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:176432


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory