Phenotypes Associated with This Genotype

Genotype
MGI:5792949

• Allelic Composition: Megf10^{tm1(KOMP)Vlcg}/Megf10⁺
• Genetic Background: C57BL/6N-Megf10^{tm1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

nervous system

increased hindbrain apoptosis ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

abnormal cerebellum morphology ( J:231811 )

• increase in apoptotic cells specifically in the cerebellum at P7 but not in the adult cerebellum

abnormal astrocyte physiology ( J:231811 )

• cultured astrocytes show impaired engulfment of UV-irradiated apoptotic MEFs, with an approximate 60% reduction in engulfment compared to wild-type astrocytes indicating impaired phagocytosis of apoptotic cells