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Phenotypes Associated with This Genotype
Genotype
MGI:5790976
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (765 available)
Ptentm1Mro mutation (1 available); any Pten mutation (78 available)
Slc1a3tm1(cre/ERT2)Mgoe mutation (0 available); any Slc1a3 mutation (51 available)
Trp53tm1Brn mutation (17 available); any Trp53 mutation (210 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration
• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum
• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus
• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

nervous system
• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration
• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum
• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus
• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
high grade glioma DOID:3070 OMIM:PS137800
J:229481


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory